Grandma Wolfe was the wife of Hiram Wolfe, the mother of George Wolfe, the mother-in-law of Virginia Wolfe, adoptive paternal grandmother of Heffer Wolfe, and the biological paternal grandmother of Peter Wolfe and Cindy Wolfe. She's dead and her soul now lives in Heck.
In "Heff in a Handbasket", she appears for the first time where she refuses to spend afterlife with her grandson, saying Heffer would ruin her peace and quiet. She also told Heffer that she refused to live in Heaven, because she doesn't feel like hearing the sandal wearing Santa Clauses (angels) sing. She seems to have major power over Peaches, as he always respects and obeys her commands.
Behind the scenes
Grandma Wolfe is voiced by Charlie Adler.